Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity. However, to date, the plasma protein binding properties of AA are unknown. Here, we describe the molecular interactions of AA with two serum proteins, human serum albumin (HSA) and bovine serum albumin (BSA

Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. Scientia Pharmaceutica, 2013. Mohammad Akbarsha. Preethy Paul. Ali …

Recently, we have studied the mode of action of AA-mediated apoptosis Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands. Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Fang Cheng, Maria Sippola-Thiele, Patrik Eklund and John E Eriksson Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a co-solvents or surfactant or a combination thereof. ANISOMELIC ACID.

[ Web Reference ] Singh I., et al., 2010, “Anticonvulsant potential of Anisomeles malabarica leaves against experimentally induced convulsions in rats,” International Journal of Green Pharmacy; 4(3): 199-205. Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect By Rajendran Senthilkumar, Didem Şen Karaman, Preethy Paul, Emma M. Björk, Magnus Odén, John E. Eriksson and Jessica M. Rosenholm petroleum ether extract of plant contains a triterpenic acid known as betulinic acid [3] while the hexane extract consists of β-sitosterol and diterpenoids (ovatodiolide and anisomelic acid) [4]. The aerial parts contain anisomelolide, malabaric acid, 2-acetoxymalabaric acid, anisomelyl acetate, anisomelol and anisomelin [5]. Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica . By Christo Paul Preethy. Cite .

Pharmaceutical compositions of anisomelic acid and their use Download PDF pharmaceutical composition: cells: antiviral: apoptosis: anisomelic acid; Prior art

For some people, it's a sign of gastroesophageal reflux disease (GERD). If you're struggling to get stomach acid reli From trouble sleeping to frequent heartburn, the symptoms of acid reflux can cause discomfort, impacting your day-to-day life and your health, too. Many people — about 20% of the U.S. population, according to the National Institutes of Heal Amino acids may sound familiar from your high school biology class, but did you know that your body needs them to survive?

diterpenoids – 4, 7 – oxycyclo anisomelic acid, 4 – methylene – 5 – hydroxy ovatodiolide (I), 4 – methylene – 5 – oxo anisomelic acid. The herb is used as an astringent and carminative. It is used in folk medicine in the treatment of diverse conditions such as inflammatory skin diseases,

Acridine Orange & Ethidium Bromide (AO & EB) and Hoechst 33258 WO2014033366A1 PCT/FI2013/050828 FI2013050828W WO2014033366A1 WO 2014033366 A1 WO2014033366 A1 WO 2014033366A1 FI 2013050828 W FI2013050828 W FI 2013050828W WO 2014033366 A1 WO201 Anisomelic acid (AA) (Fig.

AA is revealed to hold a novel action modality based on specific targeting of the HPV oncoproteins, which restores p53-mediated growth arrest and induces apoptosis by terminating E6-mediated cIAP2 stabilization.
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It is used in folk medicine in the treatment of diverse conditions such as inflammatory skin diseases, Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Rajendran Senthilkumar1, Yury Brusentsev2, Preethy Paul1, Fang Cheng1, Maria Sippola-Thiele1, Patrik Eklund2 and John E Eriksson1 1Turku Centre of Biotechnology, Finland 2Abo Akademi University, Finland Targeted delivery of a new anticancer compound Anisomelic acid using chitosan-coated porous silica nanorods for an enhanced apoptotic effect in vitro by Rajendran Senthilkumar a, Didem Şen Karamanb, Preethy Paula, Emma M. Björkc, Magnus Odénc, John E. Eriksson*,a and Jessica M. Rosenholm*,b Preethy C.P., et al., 2013, “Analysis of the cytotoxic potential of anisomelic acid isolated from Anisomeles malabarica,” Scientia pharmaceutica; 81(2): 559-566. [ Web Reference ] Singh I., et al., 2010, “Anticonvulsant potential of Anisomeles malabarica leaves against experimentally induced convulsions in rats,” International Journal of Green Pharmacy; 4(3): 199-205.

diterpenoids – 4, 7 – oxycyclo anisomelic acid, 4 – methylene – 5 – hydroxy ovatodiolide (I), 4 – methylene – 5 – oxo anisomelic acid. The herb is used as an astringent and carminative. It is used in folk medicine in the treatment of diverse conditions such as inflammatory skin diseases, Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Rajendran Senthilkumar1, Yury Brusentsev2, Preethy Paul1, Fang Cheng1, Maria Sippola-Thiele1, Patrik Eklund2 and John E Eriksson1 1Turku Centre of Biotechnology, Finland 2Abo Akademi University, Finland Targeted delivery of a new anticancer compound Anisomelic acid using chitosan-coated porous silica nanorods for an enhanced apoptotic effect in vitro by Rajendran Senthilkumar a, Didem Şen Karamanb, Preethy Paula, Emma M. Björkc, Magnus Odénc, John E. Eriksson*,a and Jessica M. Rosenholm*,b Preethy C.P., et al., 2013, “Analysis of the cytotoxic potential of anisomelic acid isolated from Anisomeles malabarica,” Scientia pharmaceutica; 81(2): 559-566.
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Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands. Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Fang Cheng, Maria Sippola-Thiele, Patrik Eklund and John E Eriksson.

Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles malabarica. Recently, we have studied the mode of action of AA-mediated apoptosis, indicating 1987-01-01 · Anisomelic acid is found in the South Indian medicinal plant Amsomeles malabauta R.Br.l, whereas the lobohedleolides are constituents of the soft coral Lobophytum hedlejt Whitelegge, which inhabits a region of Okinawa.2 Lobohedleolide inhibits growth of Hella cells in vitro at 5 ug/mL.2 No specific biological activity has been reported for the other members of the triad. anisomelic acid (I) lobohedleolide (II) (7E)-lobohedleolide (111) The presence of a conjugated acid moiety at Anisomelic acid (AA) (Fig.

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The essential oil of the plant is useful in uterine affections (6). The plant yields anisomelic acid, ovatodiolide, 4,7-epoxyovatodiolide, apigenin, terniflorin B, prunin-6”-p-comarate, maslinic acid, hederagenin, and arjunolic acid (6,7).

Anisomeles malabarica has been shown to possess Anisomelic Acid, as well as Anisomelolide, Malabaric Acid, 2-Acetoxymalabaric Acid, Anisomelyl Acetate and Anisomelol (Preethy et al. 2013), and essential oils.